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However, in a well-controlled study of patients with lymphoma on combination therapy, ZYLOPRIM (allopurinol) did not increase the zyloprim marrow toxicity of patients treated with cyclophos-phamide, doxorubicin, bleomycin, procarbazine, and/or mechlorethamine . Enhanced bone marrow suppression by cyclophosphamide zyloprim and other cytotoxic agents has been reported among patients with neoplastic disease, except leukemia, in the presence of ZYLOPRIM (allopurinol) .
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